South Carolina Dept. of Transportation will be closing down one lane of 385 North for Gateway Corridor construction beginning Tonight, Friday 9/27, at 9:00pm.
Detours will be posted. Essentially drivers traveling 385 North from Downtown Greenville need to pick up 85 North on approach to the Interchange.
Take 85 North, turn around at the next available exit and then pick up 385 Northbound at Exit 51-C.
Official Release from SCDOT: