Nick Mullens is set to once again start in the place of Jimmy Garoppolo, head coach Kyle Shanahan confirmed on Friday afternoon.
Mullens will have a couple familiar faces on hand as George Kittle and Deebo Samuel are both in line to play in the Sunday Night Football matchup with the Eagles.
Mullens threw for 343 yards and a touchdown in the club's Week 3 win over the Jets, 36-9, his first start of the season.
