Trent Williams and Deebo Samuel are both active for 49ers in Jacksonville after not playing since October 15 in Cleveland. The newly acquired Chase Young will also make his debut after the 49ers traded for him at the October 31 trade deadline.
The 49ers (5-3) are looking to bounce back coming off their bye week after losing three consecutive games. Jacksonville is also coming off their bye week and have won five straight after a 1-2 start. San Francisco will be without starting left guard Aaron Banks. Banks is out with a toe injury with Jon Feliciano expected to start in his place.