The 49ers (5-1) lost for the first time in nearly a calendar year as the Browns beat San Francisco 19-17 in Cleveland on Sunday. Jake Moody missed a 41-yard field goal in the final seconds after the Brock Purdy drove down for a potential win with completions to Brandon Aiyuk and Jauan Jennings.
The loss was compounded by the loss of both Deebo Samuel and Christian McCaffrey to injuries. Samuel injured his shoulder in the second quarter and did not return while McCaffrey injured his oblique in the third quarter, was checked out on the sideline before returning for one play and then leaving the game for good.