The Saints on Tuesday were dealing with a Covid-19 outbreak which was mostly impacting the offensive coaching staff.
A "handful" of offensive coaches tested positive for the virus, the Saints announced, while Adam Schefter of ESPN reported that one player and a team nutritionist had also tested positive.
The identities of the stricken coaches were not yet announced, and their status for Sunday's game against the Panthers in Charlotte, N.C., was unclear.
Those who are vaccinated and test positive are eligible to return as soon as they are asymptomatic and test negative twice at least 24 hours apart, per league protocols.
A team source seemed unfazed by the news, reportedly saying "We'll be just fine," according to Schefter.
The Saints' offense looked as good as ever in the team's season-opening win over the Packers, racking up 38 points on the strength of five touchdown passes from new starting quarterback Jameis Winston.
Last year, Saints head coach Sean Payton was one of the first prominent figures in the NFL to reveal he had tested positive for coronavirus.
Payton later said he felt fortunate to have had only mild symptoms, and he also donated blood plasma in the hope that his antibodies could help others suffering from more serious disease.