Note: Thursday Night Football is finished for the 2021 season, and there is not a Monday Night Football game in Week 18
Saturday 4:30 p.m. ET
- Kansas City Chiefs at Denver Broncos on ESPN: Chris Fowler and Kirk Herbstreit
Saturday 8:15 p.m. ET
- Dallas Cowboys at Philadelphia Eagles on ESPN: Steve Levy, Brian Griese and Louis Riddick
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1:00 p.m. ET Window
- Green Bay Packers at Detroit Lions on FOX: Kevin Burkhardt and Greg Olsen
- Indianapolis Colts at Jacksonville Jaguars on CBS: Greg Gumbel and Adam Archuleta
- Washington Football Team at New York Giants on FOX: Chris Myers and Daryl Johnston
- Chicago Bears at Minnesota Vikings on FOX: Gus Johnson and Aqib Talib
- Tennessee Titans at Houston Texans on CBS: Andrew Catalon and James Lofton
- Pittsburgh Steelers at Baltimore Ravens on CBS: Ian Eagle and Charles Davis
- Cincinnati Bengals at Cleveland Browns on FOX: Kenny Albert and Jonathan Vilma
4:25 p.m. ET Window
- San Francisco 49ers at Los Angeles Rams on FOX: Joe Buck and Troy Aikman
- Carolina Panthers at Tampa Bay Buccaneers on CBS: Jim Nantz and Tony Romo
- Seattle Seahawks at Arizona Cardinals on FOX: Adam Amin and Mark Schlereth
- New England Patriots at Miami Dolphins on CBS: Spero Dedes and Jay Feely
- New Orleans Saints at Atlanta Falcons on FOX: Kevin Kugler and Mark Sanchez
- New York Jets at Buffalo Bills on CBS: Kevin Harlan and Trent Green
Sunday Night Football
- Los Angeles Chargers at Las Vegas Raiders on NBC: Al Michaels and Cris Collinsworth
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