Browns wide receiver Jarvis Landry was placed on injured reserve due to a knee injury on Tuesday.
The five-time Pro Bowler will miss a minimum of three weeks.
The move comes after Landry was already considered questionable after he suffered a sprained MCL early in the Browns' win over the Texans in Week 2.
On Monday, head coach Kevan Stefanski had dubbed Landry's outlook as "week-to-week."
Landry, an eight-year veteran, has six catches on the season -- including one during which he was injured, against Houston.
He averaged nearly 79 receptions in each of his first three seasons with the Browns, playing in 47 of 48 possible games in that time. The lone missed game -- the only one of his career -- came last season due to Covid protocols.
Landry has 642 career catches for 7,108 yards and 35 touchdowns.
Earlier in the week, Browns teammate Kareem Hunt said the prospect of losing Landry for any amount of time was a big setback.
“We lose a big time leader, the mentality and a playmaker,” running Hunt said. “I can’t wait for him to get healthy and get back out there.”
Landry's absence means he's likely to miss the potential upcoming return of fellow wide receiver and former LSU teammate Odell Beckham Jr.
The Browns were set to host the Bears at 1 p.m. on Sunday. Both teams are 1-1.