Fuller had been listed as questionable for the game with a hamstring injury. He was limited in practice throughout the week.
Fuller missed three straight games this season after suffering a hamstring injury against the Oct. 20 against the Indianapolis Colts. He returned in the Texans' second game against the Colts, when he caught seven passes for 140 yards.
Fuller had just one catch for eight yards in last week's win against the New England Patriots.
On the season, Fuller has 42 catches for 598 yards and three touchdowns.