The 25-year-old Civale allowed five hits and narrowly missed a shutout when Pittsburgh pushed across a run with Josh Bell’s sacrifice fly in the ninth.
Carlos Santana broke open a scoreless game with a three-run homer in the sixth inning. Domingo Santana added a bases-clearing double in the eighth as the Indians improved to a season-best six games over .500 (15-9).
Santana turned on a full-count cutter from reliever Dovydas Neverauskas (0-3) and sent it over the right-field seats for his third home run of the season.
Pittsburgh’s National League-worst batting average dropped to .211 when it failed to muster much of anything against Civale. The Pirates have dropped 13 of 15 and their 4-16 record is the worst in the major leagues.