Stanton Negley Drug is closing at the end of August.
There's a sign on the door of the East End independent pharmacy notifying customers business will end on Saturday, August 30.
On that day, Stanton Negley will finish a long run.
The Pittsburgh Business Times reports it was incorporated in 1882.
Pharmacies are operating in a difficult environment as health insurers and pharmacy benefits managers are making reimbursements on medications unprofitable.