The 2026 WalletHub study on the fattest cities in America highlights a stark regional contrast, ranking the Greenville-Anderson-Mauldin metro area as the 15th most overweight and obese city in the nation. This ranking, based on 19 key metrics including adult obesity rates and access to healthy food, places Greenville among the heaviest in the South, trailing just behind fellow South Carolina cities like Columbia at 11th. Conversely, the report identifies Asheville, North Carolina, as a regional outlier, boasting the lowest percentage of obese adults of all 100 cities surveyed. While cities like Honolulu and Seattle often trade the title of overall "least fat," Asheville's standing as a leader in weight-related health provides a sharp contrast to the obesity challenges facing its neighbor just across the state line.
