Illinois State Police say the first crash happened near 37th on the inbound Dan Ryan Expressway around 12:45 a.m.
Troopers responded to a two-vehicle crash on I-94 and found two people injured. Both were taken to a nearby hospital, where one person later died.
All local lanes were closed and reopened around 5:30 a.m. with no other injuries being reported.
In a separate crash, troopers responded to a fatal two-car collision on the outbound Eisenhower Expressway near Austin on the city's west side.
One person was taken to the hospital where they later died.
ISP says all westbound I-290 lanes were closed until about 7 a.m. with IDOT on the scene.
