The Patriots have already designated five players as out for Sunday's game against Houston.
After ruling Shaq Mason, Trent Brown and Shaun Wade as out Friday, they downgraded Jalen Mills and Ronnie Perkins to out on Saturday.
Perkins has been a healthy scratch this season, but Mills has started every game at cornerback. With Wade also out, this likely means lots of playing time for Joejuan Williams opposite of JC Jackson.
Not only will the offensive line have a number of backups playing a lot, so will the secondary.
At 1-3, the Patriots desperately need a win.
