Rizzo has missed the past four games because of the ailment, which caused him to exit early in a loss last Saturday, the last time he played.
Victor Caratini -- who homered twice and drove in all four of the Cubs' runs in a 4-1 win against the Mets on Thursday night -- will start at first base. Third baseman Kris Bryant is also out of the lineup for a day of rest.
Rizzo is expected to be "fine" with rest, manager Joe Maddon has said previously. Rizzo is hitting .290 with 25 homers, 82 RBIs and a .928 OPS in 125 games.
In a roster move Friday, the Cubs activated left-hander Cole Hamels from the paternity list. He didn't miss a start, and he's schedule to take the mound Saturday.
The Cubs host the Brewers at Wrigley Field, with first pitch set for 1:20 p.m. Pregame starts at 12:45 p.m.