You might remember the nearly 15 ton granite Sphinx, which was moved from the basement in the complex in June and rolled into the main entrance hall.
You'll get to see it for the first time in its new location this weekend.
And, you'll see a number of treasures that were brought out of storage and placed in new displays.
The Penn Museum's Ellen Owens says visitors will also be treated to a host of live performances.
"Dance performances on Saturday by Universal African Dance and Drum Ensemble, and a Mayan dance and marimba group called Maya AWAL," Owens said.
And there will be kid-friendly activities as well.
"You can learn to write hieroglyphs, you can make really cool stamped fabric patterns that are related to Mexico and Central America and Africa," she said.
A wide variety of experts will also be on hand this weekend to make the museum experience extra special.
"From the curators that have designed the galleries that have lots of incredible academic knowledge to our new global guides, who are people that are trained to give tours but also tell personal stories," she added.