Philadelphia police say shortly after 5 p.m. Wednesday, officers were called to the parking lot of a drug store along North Broad Street near Wyoming Avenue.
Officials say when officers arrived, they were informed a pharmacist administered Naloxone — used to reverse the effects of opioids — to a man before police arrived.
Police say officers saw the man getting increasingly agitated, and he began screaming. He allegedly started to strike cars and the ground with his body.
Police say for safety reasons, officers were attempting to get the man in handcuffs. There was a struggle, and a police officer allegedly hit the man with a closed fist in the face and head.
The man was ultimately restrained.
While being transported to an area hospital, officials say the man died in the ambulance. Attempts to resuscitate him were unsuccessful.
In a written statement, Commissioner Danielle Outlaw said "any loss of life brings pain, sadness, and questions for all involved." She added a thorough investigation will be conducted.