GLP-1 medications have surged in popularity for weight loss, with prescriptions skyrocketing in recent years. While these drugs can help patients shed pounds, they are not a permanent solution. Most people regain nearly 70% of lost weight within a year of stopping treatment, and long-term effects remain uncertain. Side effects like nausea, vomiting, and even pancreatitis add to the challenges, along with high costs, and inconsistent insurance coverage.
Why surgery works better
Metabolic (bariatric) surgery remains the most effective and lasting treatment for severe obesity. These procedures alter the stomach and intestines, triggering hormonal changes that reduce hunger, increase fullness and improve how the body processes food. Unlike medications that target one or two pathways, surgery resets multiple systems for a more comprehensive impact.
The benefits can include:
- Up to 75% excess weight loss within a year
- 10+ years of sustained results
- Lower risk of obesity-related diseases like diabetes and heart disease
- Reduced risk of premature death by up to 50%
These surgeries are also very safe, often less risky than common procedures like gallbladder removal.
Can they work together?
GLP-1 medications and metabolic surgery aren’t competing options, they can complement each other. Some patients start with medication and later choose surgery for permanent results, while others use GLP-1s after surgery to manage weight regain. Your doctor can help determine the best approach for your goals.
Expert care at Loyola Medicine
Loyola’s nationally recognized Center for Metabolic Surgery & Bariatric Care offers both surgical and non-surgical programs. Our multidisciplinary team provides personalized plans and ongoing support to help you achieve lasting health.
Learn more about your options at loyolamedicine.org/weight-loss-bariatrics.