St. Paul police say the city's second reported homicide of the year happened early overnight in the Dayton's Bluff neighborhood.
The call came in from the 1400 block of Sixth Street East just before midnight.
"Officers arrived on the scene, they located an adult male victime suffering from multiple stab wounds," said St. Paul police sergeant Troy Vixavong.
The man, believed to be in his 20's, died after he was taken to Regions Hospital.
The house where the stabbing victim was found is near Harding High School.
There are no arrests and police say anyone with information on the incident should contact them.