The Buffalo Bills are back on the road this week, looking to improve to 6-2 this season as they take on the 1-6 Jacksonville Jaguars at TIAA Bank Field.
Buffalo is coming off a 26-11 win over the Miami Dolphins last week in Orchard Park, completing a season sweep of the Bills' division rival. It also marked the seventh-straight win over the Dolphins since 2018, which is a new franchise record.
This will be the second-straight week the Bills are taking on a team with a single win for the season, with Jacksonville getting their only win in London back in week 6 against the Dolphins.

Jacksonville is led by highly touted rookie quarterback Trevor Lawrence, who was drafted first overall by the Jaguars in the 2021 NFL Draft. Despite being the top pick in the draft, Lawrence has struggled to start his rookie season, completing just 59.6% of his passes for 1,703 yards, eight touchdowns and nine interceptions.
Even with the struggles right off the bat in Jacksonville, Bills head coach Sean McDermott knows just how good Lawrence can be under center in the NFL.
“You can see the skill. He can make every throw," McDermott said during his weekly Friday appearance on the “Extra Point Show” with Sal Capaccio and "Sneaky Joe" DiBiase. "I’m sure he’s going to have a great career, and he's off to a great start.”
The Bills are currently the best team in the NFL in terms of turnover differential, forcing a total of 18 turnovers while giving the ball away five times. McDermott commended his team on Friday for not only taking the ball away at the rate they do, but for also keeping the ball in their own hands.
“The turnover differential is an all team stat, and our guys, up to this point, have used it to their advantage,” McDermott said.
The one concern for the Bills heading into Sunday's matchup in Jacksonville is the handful of injuries his team is dealing with. Buffalo's injury report on Thursday saw wide receiver Cole Beasley, offensive tackle Spencer Brown, guard Jon Feliciano, tight end Dawson Knox, defensive tackle Star Lotulelei and safety Jordan Poyer all listed as non-participants on the injury report.
McDermott confirmed on Friday that Knox will miss a second-straight game as he continues to rehab a broken hand. Meanwhile, Feliciano will also be out this weekend as he deals with a calf injury that will have him out on a week-to-week basis.
According to the final injury report of the week on Friday, the Bills will also be without Brown due to his back injury, while Beasley and Poyer are both listed as "questionable".
Kickoff on Sunday between the Bills and Jaguars is slated for 1 p.m. ET with John Murphy, Eric Wood and Sal Capaccio on the call along the Bills Radio Network.
You can listen to McDermott's entire interview during the “Extra Point Show" below:
