Villanova is 6-1 (3-1 CAA) and ranked as high as fifth in the country in FCS.
The Wildcats are also coming off a bye week.
"It also coincided with our fall break," Villanova head coach Mark Ferrante said of the bye. "So our guys not only were able to refresh a little bit and take a little step back from the physical part of the season, they also were able to clear their minds and get off of campus a little bit, go home, see their families and didn't have class. So the mental stress of midterms and all that is behind us now as well."
The Wildcats last played on Oct. 12, when they lost a hard-fought match-up at #2 James Madison, 38-24.
Stony Brook is 4-3 (1-2 CAA) this season and coming off a 20-14 home loss to New Hampshire this past Saturday.
"They're really good," Ferrante said. "They have good size up front on both sides of the ball. They have an aggressive style of play on both sides of the ball. The collection of wideouts is really good, the quarterback's an athletic guy."
That quarterback is redshirt junior Tyquell Fields, who has thrown for 1,436 yards and nine touchdowns while rushing for 253 yards and two additional scores.
Last season, Stony Brook beat the Wildcats 29-27 at home. The Seawolves rallied from a 21-0 deficit to win that one.
Stony Brook is coached by Chuck Priore, the older brother of Penn head coach Ray Priore.
Saturday's game at Villanova Stadium kicks off at 3:30 p.m.
You can follow Matt on Twitter @Mattleon1060.