Fuller, who is dealing with a groin injury, has been a limited participant in practice all week and is officially listed as questionable for Saturday.
"I would say that that’ll be a game-time decision," Texans head coach Bill O'Brien said Thursday. "I think we're going to practice today, we'll see how it goes today. He'll be out there today and then we'll do some more tomorrow and then we'll see how it goes."
The fourth-year wide receiver missed five games this season and exited two of them early, mostly due to hamstring and groin injuries.
Houston's offense is noticeably different with Fuller in the lineup because of his speed.
Fuller has nine receptions of 30-or-more yards, which is tied for seventh-most in the NFL, despite him missing so much time.
In Week 14 against the Indianapolis Colts, after missing a month of action, Fuller returned to put up 140 receiving yards on seven catches, including a 51-yard reception from Deshaun Watson in the fourth quarter.
Also listed as questionable for Saturday: cornerbacks Bradley Roby and Johnathan Joseph (both with hamstrings), safety Jahleel Addae (Achilles), and tight end Jordan Akins (hamstring).
Left tackle Laremy Tunsil (ankle) had been limited in practice this week but was a full participant Thursday.